ISNTD Chagas

Progress through partnership

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Dr. Edward L. D'Antonio

Assistant Professor of Biochemistry and Structural Biology

University of South Carolina Beaufort

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His team consists of undergraduate researchers that utilize a variety of techniques, including: analytical chemistry, biotechnology, enzymology, structural biology, and synthetic chemistry. He uses structure-based drug design methodology to develop new classes of competitive inhibitors for enzyme drug-targets found in parasites of trypanosomatid diseases.  These diseases include Chagas' disease (Trypanosoma cruzi), human African trypanosomiasis (Trypanosoma brucei), and leishmaniasis (Leishmania spp.). He has a focus on pentose phosphate pathway enzymes, which are known to be critically important for the survival of these parasites.  Since human cells usually have similar enzymes of these drug-targets, our drug designs are created that give rise to parasite selectivity.  Another goal of hisresearch is to optimize existing inhibitor designs by increasing molecular interactions within the inhibitor's binding site.